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BN40943R-100ul
100ul
￥2360.00
交叉反應(yīng)：Human,Rat(predicted:Mouse) 推薦應(yīng)用：WB,IHC-P,ELISA
BN40943R-200ul
200ul
￥3490.00
交叉反應(yīng)：Human,Rat(predicted:Mouse) 推薦應(yīng)用：WB,IHC-P,ELISA
產(chǎn)品描述
| 英文名稱 | Adenylate cyclase 1 |
| 中文名稱 | 腺苷酸環(huán)化酶1抗體 |
| 別 名 | 3'5' cyclic AMP synthetase; ADCY1; adenyl cyclase; adenylate cyclase type I; ATP pyrophosphate lyase; Brain adenylate cyclase 1; Ca(2+)/calmodulin activated adenylyl cyclase; EC 4.6.1.1; ADCY1_HUMAN; Adenylate cyclase type 1; ATP pyrophosphate-lyase 1; Adenylate cyclase type I; Adenylyl cyclase 1; Ca(2+)/calmodulin-activated adenylyl cyclase. . |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 激酶和磷酸酶 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | Human, Rat, (predicted: Mouse, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 123kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human adenylate cyclase type I:751-850/1119 <Cytoplasmic> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | The membrane bound adenylyl cyclases (ACs) represent one of the major families of effector enzymes for G protein coupled receptors. Eight human AC isoforms (AC-1 through AC-4) have been identified up to now and genes for at least nine adenylate cyclase (AC-1-AC-9) have been cloned characterized and sequenced. This is a calmodulin-sensitive adenylyl cyclase which may be involved in regulatory processes in the central nervous system. It may play a role in neuronal plasticity, memory acquisition and learning and is expressed predominantly in the brain, retina and adrenal medulla. Function: This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Brain, retina and adrenal medulla. Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains. SWISS: Q08828 Gene ID: 107 Database links: Entrez Gene: 107 Human Entrez Gene: 432530 Mouse Omim: 103072 Human SwissProt: Q08828 Human SwissProt: O88444 Mouse Unigene: 192215 Human Unigene: 259733 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 腺苷酸環(huán)化酶(adenylate cyclase, AC) 是G蛋白偶聯(lián)受體家族之一，是膜整合蛋白,它的氨基端和羧基端都朝向細(xì)胞質(zhì)。AC在膜的細(xì)胞質(zhì)面有兩個(gè)催化結(jié)構(gòu)域,還有兩個(gè)膜整合區(qū),每個(gè)膜整合區(qū)分別有6個(gè)跨膜的α螺旋。哺乳動(dòng)物中已發(fā)現(xiàn)6個(gè)腺苷酸環(huán)化酶異構(gòu)體。由于AC能夠?qū)TP轉(zhuǎn)變成cAMP,引起細(xì)胞的信號(hào)應(yīng)答,因此,腺苷酸環(huán)化酶是G蛋白偶聯(lián)系統(tǒng)中的效應(yīng) |
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