福利姬视频在线看-福利姬图库入口-福利姬网站入口-福利姬网站在线观看-福利姬网址-福利姬下载-福利姬液液酱喷水-福利姬一区二区

最近搜索:細胞培養 微生物學 分子生物 生物化學
首頁>>免疫學>>一抗>>多聚合酶α抗體
多聚合酶α抗體
  • 產品貨號:
    BN41029R
  • 中文名稱:
    多聚合酶α抗體
  • 英文名稱:
    Rabbit anti-PAPOA Polyclonal antibody
  • 品牌:
    Biorigin
  • 貨號

    產品規格

    售價

    備注

  • BN41029R-100ul

    100ul

    ¥2360.00

    交叉反應:Mouse(predicted:Human,Rat,Dog,Pig,Cow,Horse) 推薦應用:WB,ELISA

  • BN41029R-200ul

    200ul

    ¥3490.00

    交叉反應:Mouse(predicted:Human,Rat,Dog,Pig,Cow,Horse) 推薦應用:WB,ELISA

產品描述

英文名稱PAPOA
中文名稱多聚合酶α抗體
別    名MGC5378; PAP alpha; PAP-alpha; PAP; PapIII; Plap; poly(A) polymerase alpha; Polynucleotide adenylyltransferase alpha.  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量82kDa
細胞定位細胞核 細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human PAPOA:601-700/745 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹he protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

Function:
Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus.

Subunit:
Monomer. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with FIP1L1 (By similarity). Interacts with NUDT21; the interaction is diminished by acetylation. Interacts with KPNB1; the interaction promotes PAP nuclear import and is inhibited by acetylation of PAP.

Subcellular Location:
Cytoplasm. Nucleus. Note=The 90 kDa form is nuclear while the 100 kDa and the 106 kDa forms are both nuclear and cytoplasmic.

Post-translational modifications:
Polysumoylated. Varying sumolyation depending on tissue- and cell-type. Highly sumoylated in bladder and NIH 3T3 cells. Sumoylation is required for nuclear localization and enhances PAP stability. Desumoylated by SENP1. Inhibits polymerase activity.
Hyperphosphorylation on multiple CDK2 consensus and non-consensus sites in the C-terminal Ser/Thr-rich region represses PAP activity in late M-phase. Phosphorylation/dephosphorylation may regulate the interaction between PAP and CPSF.
Acetylated in the C-terminus. Acetylation decreases interaction with NUDT21 and KPNB1, and inhibits nuclear localization through inhibiting binding to the importin alpha/beta complex.

Similarity:
Belongs to the poly(A) polymerase family.

SWISS:
P51003

Gene ID:
10914

Database links:

Entrez Gene: 10914 Human

Entrez Gene: 18789 Mouse

Entrez Gene: 314417 Rat

Omim: 605553 Human

SwissProt: P51003 Human

SwissProt: Q61183 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


















image.png

主站蜘蛛池模板: 香港三级日本三级妇人三级 | 色老头成人免费综合视频 | 亚洲欧美视频一区二区 | 国产suv精品一区二区三区 | 国产欧美精品AAAAAA片 | 乱伦黄片www.| 国禁国产you女视频网站 | 国产女人爽到高潮精品久久 | 黑蚪欧洲天堂婷婷在线观看 | 欧美日韩人妻自慰喷水一级综合 | 97人妻人人揉人人躁人人 | 国产91精品高清一区二区三区 | 国产av激情无码久久 | 丁香五月综合久久激情 | 欧亚美性色欧美性A片 | 亚洲午夜在线视频观看 | 99国产欧美另类久久久精品 | 高清一区高清二区视频 | 高清无码在线视频 | 色综合天天综合网国产成人网 | 成人自慰在线免费观看 | 成人欧美日韩 | 国产福利观看 | 欧美日韩国产大片一区 | 久久久久久久97 | 国产成人综合亚洲精品国产 | 久久国内中文字幕 | 国产亚洲欧美日韩综合 | 国产亚洲精品久久精品6 | a级毛片免费全部播放无码 a级毛片免费网站 | 99热这里只有精品91 | 久久亚洲国产精品成人av秋霞 | 18禁白丝喷水视频www | 2024中文字幕在线 | 国产精品原创在线 | 国产精品熟女高潮视频 | 国产欧美性爱亚洲成人自拍 | 久久久乱码精品亚洲日韩 | 凹凸在线无码免费视频 | 国产日韩精品一区二区三区在线观 | 免费A级毛片黄A片高清在线播放 |