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BN41160R-100ul
100ul
￥2470.00
交叉反應：Human(predicted:Chicken,Dog,Pig,Cow,Horse) 推薦應用：Flow-Cyt,ELISA
產品描述
| 英文名稱 | phospho-RUNX2 (Ser451) |
| 中文名稱 | 磷酸化成骨特異性轉錄因子抗體 |
| 別 名 | RUNX2(phospho S451); Runt-related Transcription Factor 2; CBF alpha 1; CBFA1; CCD; CCD1; Cleidocranial dysplasia 1; Core binding factor; Core binding factor runt domain alpha subunit 1; Core binding factor subunit alpha 1; MGC120023; Oncogene AML 3; OSF 2; OSF2; Osteoblast specific transcription factor 2; OTTHUMP00000016533; PEA2 alpha A; PEA2aA; PEBP2 alpha A; PEBP2A1; PEBP2A2; PEBP2aA1; Polyomavirus enhancer binding protein 2 alpha A subunit; Runt domain; Runt related transcription factor 2; SL3 3 enhancer factor 1 alpha A subunit; SL3/AKV core binding factor alpha A subunit. |
| 產品類型 | 磷酸化抗體 |
| 研究領域 | 免疫學 干細胞 轉錄調節因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, (predicted: Chicken, Dog, Pig, Cow, Horse, ) |
| 產品應用 | ELISA=1:5000-10000 Flow-Cyt=1ug/Test not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 67kDa |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human RUNX2 around the phosphorylation site of Ser451:TS(p-S)GS |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產品介紹 | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation. Subunit: Heterodimer of an alpha and a beta subunit. Interacts with HIVEP3 (By similarity). The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with G22P1 (Ku70) and XRCC5 (Ku80). Interacts with MYST3 and MYST4. Subcellular Location: Nucleus. Tissue Specificity: Specifically expressed in osteoblasts. Similarity: Contains 1 Runt domain. SWISS: Q13950 Gene ID: 860 Database links: Entrez Gene: 860 Human Entrez Gene: 12393 Mouse Omim: 600211 Human SwissProt: Q13950 Human SwissProt: Q9XSB7 Horse SwissProt: Q08775 Mouse Unigene: 535845 Human Unigene: 391013 Mouse Unigene: 391017 Mouse Unigene: 214214 Rat Unigene: 83672 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. RUNX2又稱：Cbfα1(Core-binding factor, alpha 3 subunit) 是新發現的一類調控間充質干細胞向成骨方向分化的特異性轉錄因子,參與骨形成,骨骼生長和發育的一類重要細胞,它起源于多能間充質干細胞,是間 |
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