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首頁>>免疫學>>一抗>>調亡誘導因子抗體
調亡誘導因子抗體
  • 產品貨號:
    BN41469R
  • 中文名稱:
    調亡誘導因子抗體
  • 英文名稱:
    Rabbit anti-AIF Polyclonal antibody
  • 品牌:
    Biorigin
  • 貨號

    產品規格

    售價

    備注

  • BN41469R-50ul

    50ul

    ¥1486.00

    交叉反應:Human,Mouse,Rat,Pig(predicted:Chicken,Dog,Cow,Rabbit,Sheep) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

  • BN41469R-100ul

    100ul

    ¥2360.00

    交叉反應:Human,Mouse,Rat,Pig(predicted:Chicken,Dog,Cow,Rabbit,Sheep) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

  • BN41469R-200ul

    200ul

    ¥3490.00

    交叉反應:Human,Mouse,Rat,Pig(predicted:Chicken,Dog,Cow,Rabbit,Sheep) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱AIF
中文名稱調亡誘導因子抗體
別    名Apoptosis inducing factor; Harlequin; Hq; mAIF; MGC111425; MGC5706; PDCD 8; PDCD8; Programmed cell death 8; Programmed cell death 8 isoform 1; Programmed cell death 8 isoform 2; Programmed cell death 8 isoform 3; Programmed cell death protein 8 mitochondrial; Programmed cell death protein 8 mitochondrial precursor; Striatal apoptosis inducing factor; AIFM1_HUMAN; Apoptosis-inducing factor 1, mitochondrial.  




研究領域腫瘤  細胞生物  染色質和核信號  神經生物學  細胞凋亡  細胞周期蛋白  線粒體  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat, Pig,  (predicted: Chicken, Dog, Cow, Rabbit, Sheep, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量57kDa
細胞定位細胞核 細胞漿 線粒體
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human AIF:131-230/613 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, May 2010].

Function:
Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.

Subunit:
Interacts with XIAP/BIRC4. Interacts (via N-terminus) with EIF3G (via C-terminus).

Subcellular Location:
Mitochondrion intermembrane space. Mitochondrion inner membrane. Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Colocalizes with EIF3G in the nucleus and perinuclear region.

Tissue Specificity:
Isoform 5 is frequently down-regulated in human cancers.

Post-translational modifications:
Under normal conditions, a 54-residue N-terminal segment is first proteolytically removed during or just after translocation into the mitochondrial intermembrane space (IMS) by the mitochondrial processing peptidase (MPP) to form the inner-membrane-anchored mature form (AIFmit). During apoptosis, it is further proteolytically processed at amino-acid position 101 leading to the generation of the mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis in a caspase-independent manner.
Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation. Ubiquitination at Lys-255 by XIAP/BIRC4 blocks its ability to bind DNA and induce chromatin degradation, thereby inhibiting its ability to induce cell death.

DISEASE:
Combined oxidative phosphorylation deficiency 6 (COXPD6) [MIM:300816]: A mitochondrial disease resulting in a neurodegenerative disorder characterized by psychomotor delay, hypotonia, areflexia, muscle weakness and wasting. Some patients manifest prenatal ventriculomegaly and severe postnatal encephalomyopathy. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the FAD-dependent oxidoreductase family.

SWISS:
O95831

Gene ID:
9131

Database links:

Entrez Gene: 51060 Human

Entrez Gene: 9131 Human

Entrez Gene: 26926 Mouse

Entrez Gene: 83533 Rat

Omim: 300169 Human

SwissProt: O95831 Human

SwissProt: Q9Z0X1 Mouse

SwissProt: Q9JM53 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

AIF是一種易位到細胞核誘導凋亡的線粒體蛋白, AIF可引起DNA破碎、染色質凝聚,還可誘導細胞色素C和Caspase-9從線粒體中釋放出來,AIF從線粒體中的釋放可被過度表達的Bcl-2(一種參與線粒體滲透的蛋白質)所抑制。


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