激情深爱五月-激情视频亚洲-激情视频综合网-激情四房-激情婷婷-激情婷婷丁香

最近搜索:細胞培養 微生物學 分子生物 生物化學
首頁>>免疫學>>一抗>>擴張型心肌病蛋白1G抗體
擴張型心肌病蛋白1G抗體
  • 產品貨號:
    BN41970R
  • 中文名稱:
    擴張型心肌病蛋白1G抗體
  • 英文名稱:
    Rabbit anti-Titin/CMD1G Polyclonal antibody
  • 品牌:
    Biorigin
  • 貨號

    產品規格

    售價

    備注

  • BN41970R-50ul

    50ul

    ¥1486.00

    交叉反應:Human(predicted:Mouse,Rat,Pig,Cow) 推薦應用:IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41970R-100ul

    100ul

    ¥2360.00

    交叉反應:Human(predicted:Mouse,Rat,Pig,Cow) 推薦應用:IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41970R-200ul

    200ul

    ¥3490.00

    交叉反應:Human(predicted:Mouse,Rat,Pig,Cow) 推薦應用:IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產品描述

英文名稱Titin/CMD1G
中文名稱擴張型心肌病蛋白1G抗體
別    名TTN; MPRM; Cardiomyopathy dilated 1G (autosomal dominant); CMD1G; CMH 9; CMH9; CMPD 4; CMPD4; Connectin; DKFZp451N061; EOMFC; HMERF; LGMD2J; MU RMS 40.14; Rhabdomyosarcoma antigen; Rhabdomyosarcoma antigen MU RMS 40.14; Rhabdomyosarcoma antigen MU-RMS-40.14; TITIN_HUMAN; TMD.  



研究領域心血管  信號轉導  表觀遺傳學  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Pig, Cow, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/test IF=1:50-200 (石蠟切片需做抗原修復)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量3780kDa
細胞定位細胞核 細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Titin/CMD1G:2601-2800/34350 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹Titin, also known as connectin, is a large protein involved in the temporal and spatial control of the assembly of the highly ordered sarcomeres (contractile units) of striated muscle. In addition to sarcomere assembly Titin also functions to maintain the structural integrity of the contracting myofibrils within the muscle and to organize the machinery for condensation of chromosomes in dividing cells. Titin is a giant protein composed of 27,000 amino acids and contains an autoregulated serine kinase catalytic domain as well as a calcium/calmodulin binding region that are involved in its activation. Activated Titin phosphorylates the muscle protein telethonin, a sarcomeric protein abundant in heart and skeletal muscle, implicating Titin activity in the reorganization of the cytoskeleton during myofibrillogenesis.

Function:
Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.

Subunit:
Interacts with MYOM1, MYOM2, tropomyosin and myosin. Interacts with actin, primarily via the PEVK domains and with MYPN (By similarity). Interacts with FHL2, NEB, CRYAB, LMNA/lamin-A and LMNB/lamin-B. Interacts with TCAP/telethonin and/or ANK1 isoform Mu17/ank1.5, via the first two N-terminal immunoglobulin domains. Interacts with TRIM63 and TRIM55, through several domains including immunoglobulin domains 141 and 142. Interacts with ANKRD1, ANKRD2 and ANKRD23, via the region between immunoglobulin domains 77 and 78 and interacts with CAPN3, via immunoglobulin domain 79. Interacts with NBR1 through the protein kinase domain. Interacts with CALM/calmodulin. Isoform 8 interacts with OBSCN isoform 3.

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Isoform 3, isoform 7 and isoform 8 are expressed in cardiac muscle. Isoform 4 is expressed in vertebrate skeletal muscle. Isoform 6 is expressed in cardiac tissues.

Post-translational modifications:
Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Contains 132 fibronectin type-III domains.
Contains 152 Ig-like (immunoglobulin-like) domains.
Contains 19 Kelch repeats.
Contains 1 protein kinase domain.
Contains 17 RCC1 repeats.
Contains 14 TPR repeats.
Contains 15 WD repeats.

SWISS:
Q8WZ42

Gene ID:
7273

Database links:

Entrez Gene: 7273 Human

Entrez Gene: 396682 Pig

Entrez Gene: 84015 Rat

Omim: 188840 Human

SwissProt: Q8WZ42 Human

Unigene: 134602 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.























image.png

image.png

image.png

主站蜘蛛池模板: 国产盗摄视频手机在线 | 成人免费视频无码视在线 | 亚洲丁香婷婷久久一区二区 | 国产成a人亚洲精ⅴ品无码樱花 | 成人网站站美女拍拍拍免费视频 | 亚洲国产丝袜一区二区 | 日韩亚洲自拍黄色在线免费 | 精品玖玖玖视频在线观看 | 国产国语在线播放视频 | 国产在线a视频 | 国产精品青| 免费大片一级a一级久久无码 | 久久9精品区-无套内射无码 | videos日本熟妇人妻多毛 | 久久久久久久久久久大尺度免费视频 | 精品一区二区三区无码免费直播 | 久热精品视频在线播放 | 成人精品区一本二本 | 精选国内外好片免费收看 | 91福利国产在线 | 精品国产三级a在线欧 | 99久久九九国产精 | 精品国产三级a∨在线观看 精品国产三级a∨在线欧美 | 国产白丝jk制服在线视频 | 亚洲三级国产 | 无码av中文一二三区 | 国产无套乱子伦精彩是白视频 | 国产一区二区三区视频精品 | 亚洲精品久久久久久AV | 国产精品免费aⅴ片在线播放 | 亚洲一区二区三区不卡视频 | 国产福利一区二区三区视频在线 | 99久久综合狠狠综合久久 | 国产寡妇亲子伦一区二区三区四区 | 国产精品成人va在线播放 | 国产精品哺乳在线看还在哺乳 | 午夜久久免费视频 | 久久精品国产精品亚洲精品 | 2024国产最新盗摄在线播放 | 国产a一级毛片精品高清乱码 | 国产精品久久久久久 |